尿道微生物群与良性前列腺增生症的临床病理特征有关
Antonio C H Mariotti1, Vitor Heidrich2,3, Lilian T Inoue2
1Instituto de Ensino e Pesquisa, Hospital Sírio-Libanês, São Paulo, Brazil.
The Prostate
|November 14, 2023
概括
良性前列腺增生症 (BPH) 患者的尿路微生物群与前列腺体重和PSA水平相关. 特定的细菌,如乳杆菌和链球菌,显示与BPH临床病理特征相关的丰度变化.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 微生物组研究 微生物组研究
- 医学科学 医学科学 医学科学
背景情况:
- 良性前列腺增生 (BPH) 与下泌尿道症状 (LUTS) 有关.
- 尿路微生物群在BPH中的作用及其与临床病理学参数的相关性仍然未得到充分研究.
研究的目的:
- 在接受手术的BPH患者中调查尿路微生物群和临床病理参数之间的关联.
主要方法:
- 来自41名BPH患者的导管尿样的16S rRNA基因测序.
- 基于临床参数的尿路微生物群多样性和组成的分析.
主要成果:
- 更高的前列腺体重和PSA水平与增加的尿路微生物群α多样性相关.
- 前列腺重量与链球菌的丰富度相反相关;PSA水平与乳酸菌的丰富度正相关.
- 5α-减少酶抑制剂治疗显示与整体微生物群组成的关联,包括增加的Corynebacterium和Anaerococcus.
结论:
- 在BPH患者的尿道微生物群与临床病理特征有关.
- 这些发现支持进一步研究尿路微生物群和BPH之间的因果关系.
相关概念视频
Urinary Tract Infection II: Pathophysiology
18
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
18
Urinary Tract Infection I: Introduction
22
Urinary tract infections (UTIs) impact various parts of the urinary system, including the kidneys, ureters, bladder, and urethra. These infections are generally bacterial, with Escherichia coli being the most common causative agent, often originating from the gastrointestinal tract. However, other bacteria, such as Staphylococcus saprophyticus, Klebsiella pneumoniae, and Proteus mirabilis, are also known to cause UTIs. The type, location, and underlying complexity of the UTI guide both...
22
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care
14
A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
14
Acute Pyelonephritis I: Introduction
20
Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such...
20
Urinary Bladder
822
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
822
Anatomy of the Genitourinary System II: Bladder and Urethra
125
The lower urinary system consists of the urinary bladder and urethra, which are essential in storing and expelling urine from the body. Together with the internal and external sphincters, these structures work together to regulate urination effectively.Anatomy of the BladderThe urinary bladder is a muscular, stretchable organ behind the pubic bone and in front of the rectum. In females, the bladder is positioned anterior to the vagina and inferior to the uterus, while in males, it is located...
125


