选择性血清素再吸收抑制剂使用与通过回顾性分析发展易怒肠综合征之间的关联
Nayoung Kwak1, Hankil Lee2,3, Beom Kyung Kim4,5,6
1Graduate Program of Industrial Pharmaceutical Science, Yonsei University, Incheon, Korea.
Journal of gastroenterology and hepatology
|November 14, 2023
概括
选择性血清素再吸收抑制剂 (SSRI) 的使用与患上刺激性肠综合征 (IBS) 的风险更高有关. 这种风险在高剂量的SSRI和没有先前精神病药物治疗史的人群中特别高.
科学领域:
- 胃肠病学 胃肠病学
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 血清素在肠道微生物组平衡中起着重要作用.
- 已知选择性血清素再吸收抑制剂 (SSRI) 能够影响刺激性肠综合征 (IBS).
研究的目的:
- 评估SSRI使用和随后发生IBS之间的现实世界联系.
- 调查SSRI启动后IBS发展的风险因素.
主要方法:
- 使用多变量Cox比例危险模型与大型国家医疗保险索赔数据库 (2010-2019) 一起使用.
- 使用倾向性得分匹配来选择可比的非SSRI用户群.
- 亚组分析检查了SSRI使用点,累积剂量和持续时间,并对以前没有使用精神病药物的患者进行了额外分析.
主要成果:
- 与非SSRI使用者相比,SSRI使用者患IBS的风险高1.54倍.
- 在近期,重度和短期的SSRI使用者中观察到高风险 (HRs从2.22到4.83).
- 在没有精神病药物病史的患者中,使用SSRI后IBS发病率的风险显著增加 (HR: 1.61).
结论:
- 使用SSRI与随后IBS的风险增加有关.
- 较高的SSRI剂量和缺乏先前的精神病药物治疗史是SSRI开始后发展IBS的重要危险因素.
相关概念视频
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