非酒精性脂肪肝疾病与2型糖尿病患者的脑功能障碍有关,而没有认知障碍
Xin Li1, Wen Zhang1,2,3, Yan Bi4
1Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Diabetes, obesity & metabolism
|November 14, 2023
概括
患有2型糖尿病和非酒精性脂肪肝疾病的患者表现出与代谢问题相关的大脑功能受损. 管理血糖,脂质和肥胖可能会保护大脑健康.
科学领域:
- 神经成像是一种神经成像.
- 代谢障碍 代谢障碍 代谢障碍
- 糖尿病研究 糖尿病研究
背景情况:
- 2型糖尿病 (T2D) 与代谢功能障碍有关.
- 非酒精性脂肪肝疾病 (NAFLD) 经常与T2D同时发生,可能会加剧并发症.
- 对于T2D患者的脑部健康,尤其是同时出现的NAFLD患者,需要进一步调查.
研究的目的:
- 调查T2D患者和没有NAFLD的神经静态和动态内在活性.
- 分析大脑功能的内部/网络间拓变化.
- 评估大脑功能与代谢参数之间的关系.
主要方法:
- 功能性磁共振成像 (fMRI) 用于T2D患者的NAFLD (T2NAFLD),T2D没有NAFLD (T2noNAFLD),和健康的对照 (HCs).
- 独立组件分析确定了网络连接性和时间性质.
- 统计分析包括ANCOVA,部分相关性和正统相关性.
主要成果:
- 与T2noNAFLD患者相比,T2NAFLD患者的代谢概况 (葡萄糖,脂质,胰岛素抵抗,肥胖) 更差.
- 二型糖尿病患者表现出大脑网络拓学障碍,不论他们的认知状态如何.
- 与T2noNAFLD患者相比,T2NAFLD患者在特定网络参数中的减少更为明显.
- 改变的大脑功能与葡萄糖水平,高脂胆固醇和腰部和部比率相关.
结论:
- 二型糖尿病患者,特别是那些患有NAFLD的患者,经历了显著的大脑功能变化.
- 神经成像揭示了导致T2NAFLD脑损伤的潜在病理生理过程.
- 代谢控制 (血糖,脂质,肥胖) 对于减轻T2D患者脑损伤风险至关重要.
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