监测SARS-CoV-2的变种,以告知风险评估
Homa Attar Cohen1, Samuel Mesfin1, Juniorcaius Ikejezie1
1World Health Organization (WHO) Health Emergencies Programme, WHO, Avenue Appia 20, 1211Geneva, Switzerland.
Bulletin of the World Health Organization
|November 14, 2023
概括
早期检测和监测严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 变种对公共卫生至关重要. 整合基因组,流行病学和基于事件的数据有助于风险评估和流行病应对指导.
科学领域:
- * 病毒学和流行病学
- * 基因组监测 * 基因组监测
- * 公共卫生政策 公共卫生政策
背景情况:
- *众多严重急性呼吸综合征冠状病毒2 (SARS-CoV-2) 变种的出现对全球健康产生了重大影响.
- *了解变种的演变和传播对于评估公共卫生风险至关重要.
- *自COVID-19大流行开始以来,全球基因组测序能力迅速增加.
研究的目的:
- *为了描述2020年1月至2023年6月期间流传的全球SARS-CoV-2变种.
- *分析变异演变的遗传驱动因素及其流行病学影响.
- * 提出未来针对SARS-CoV-2可持续基因组监测的方向.
主要方法:
- *对全球SARS-CoV-2变种及其遗传特征的审查.
- * 流行病学数据和不同地区传播的变种的分析.
- *通过世卫组织伙伴关系将基因组监测与流行病学和基于事件的数据整合起来.
主要成果:
- *详细描述主要的SARS-CoV-2变种及其遗传特征.
- *评估变种对感染,住院和死亡的流行病学影响.
- * 展示综合监测如何支持风险评估和流行病应对.
结论:
- *基因组监测对于及时,基于证据的公共卫生决策至关重要.
- *未来的监测应优化变种检测,协调实验室评估,链接遗传和临床数据,并扩展到其他病原体.
- *环境监测和国际合作是可持续基因组监测的关键.
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