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在凯尼克酸诱导的中,格林的神经保护作用:行为,生化和功能见解
Mohammad Faizan1, Iram Jahan2, Mohd Ishaq1
1Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India.
概括
中的一种化合物trigonelline通过改善行为和减少神经炎症和神经元损伤来治疗,在kainic酸诱导的模型中显示出有前途.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 生物化学 生物化学
背景情况:
- 格 (Trigonella foenum-graecum L.) 中的一种类化合物trigonelline具有已知的神经保护性.
- 凯尼酸诱导的是一种广泛使用的模型,用于研究和测试潜在的抗治疗方法.
- 在这种特定的模型中,素的抗作用以前没有被研究过.
研究的目的:
- 为了评估trigonelline在甲酸诱导的老鼠模型中的潜在抗作用.
- 评估蛋白对行为缺陷,神经保护,氧化应激和炎炎症的影响.
主要方法:
- 在使用单次皮下注射开因酸剂 (10 mg/kg) 的老鼠中诱导了.
- 特里戈内林 (100 mg/kg) 或埃索苏西米德 (187.5 mg/kg) 通过腹腔内给药,持续14天.
- 进行了行为测试 (NOR,OFT,Plus Maze),生物化学分析 (水平,LDH,血清素,氧化/炎症标志物).
主要成果:
- 特里戈内林显著改善了行为结果,减少了焦虑和记忆障碍.
- 该化合物显著降低了内突触体内水平和LDH活性,表明细胞毒性降低和海马神经元损伤.
- 特里戈内林显著降低了炎症性细胞因子和氧化应激指标的水平.
结论:
- 在凯尼克酸诱导的模型中,trigonelline显示出显著的抗潜力.
- 它的治疗效益与改善行为,神经保护和调节炎症和氧化应激有关.
- 特里戈内林作为治疗管理的治疗剂显示出前途.
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