暴露组与儿童大脑发育之间的多层网络关联
Ivan L Simpson-Kent1,2, Mārtiņš M Gataviņš2,3, Ursula A Tooley2,4,5,6
1Institute of Psychology, Developmental and Educational Psychology Unit, Leiden University, Leiden, the Netherlands.
bioRxiv : the preprint server for biology
|November 14, 2023
概括
孩子 孩子 孩子 孩子
科学领域:
- 神经科学是一个神经科学.
- 环境健康 环境健康
- 发展心理学 发展心理学
背景情况:
- 贫困社区与儿童学术和健康问题的风险增加有关.
- 了解环境对儿童大脑发育的影响对于早期干预至关重要.
研究的目的:
- 研究儿童环境暴露与他们的大脑结构和功能之间的关系.
- 利用多层网络分析,将环境因素与神经发育联系起来.
主要方法:
- 构建的暴露组包括家庭的社会经济地位,儿童的逆境暴露,以及社区特征 (SES,犯罪,毒素).
- 利用多层网络分析将暴露组数据与大脑结构 (皮层厚度,表面积) 和功能 (参与率,聚类系数) 的测量结果联系起来.
- 分析了社区样本中的4-10岁儿童的数据.
主要成果:
- 在暴露和大脑层内发现了密集的连接,以及它们之间的稀疏连接.
- 较低的家庭收入与较薄的视觉皮层相关,这表明早期成熟区域的发展加速.
- 较高的邻里水平与增加的默认模式网络隔离有关,这表明毒素对大脑中线的影响.
结论:
- 多层网络分析有效地弥合了环境和神经数据,以了解儿童的发展.
- 特定的环境因素,如贫困和暴露,对儿童的大脑发育有可衡量的影响.
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