性和教育改变了主观认知衰退和粉样蛋白病理之间的关联
medRxiv : the preprint server for health sciences
|November 14, 2023
概括
主观认知衰退 (SCD) 可能表明早期阿尔茨海默病 (AD) 变化,特别是在男性和受过高等教育的人群中. 较高的SCD与粉样蛋白积累增加有关,这是早期的AD生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 生物标志物 生物标志物
背景情况:
- 主观认知衰退 (SCD) 是痴呆症的潜在早期指标.
- 它与阿尔茨海默病 (AD) 生物标志物的关联可能因教育和性别而异.
研究的目的:
- 调查教育和性别如何影响非痴呆老年人SCD和AD生物标志物之间的关系.
- 确定SCD是否可以预测特定人口群体的早期AD病理.
主要方法:
- 对156名非痴呆老年人的脑脊液 (CSF) AD生物标志物 (Aβ42,Aβ42/40,p-tau,tau,NfL) 的分析.
- 评估SCD,性别和教育水平 (使用阅读能力作为代理).
- 统计建模以检查SCD,性别和AD生物标志物上的教育之间的相互作用.
主要成果:
- 较高的SCD与较低的粉样蛋白-β 42 (Aβ42) 和Aβ42/40比率相关,表明粉样蛋白积累增加.
- SCD与性别相互作用,在男性中与较低的Aβ42/40有更强的关联.
- SCD与教育相互作用,高等教育加强了SCD和粉样蛋白标记物之间的负相关性.
结论:
- 主观认知衰退与老年人的早期阿尔茨海默氏症粉样蛋白病理学有关.
- 对于早期AD大脑变化的SCD的预测价值在男性和受过高等教育的人群中更为明显.
- SCD与tau病理或神经退行症标志物没有相关性;性别和教育是SCD评估的关键因素.
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