压力激活的脑肠回路破坏了肠道屏障的完整性和社会行为
Scott Russo1, Kenny Chan1, Long Li1
1Icahn School of Medicine at Mount Sinai.
Research square
|November 14, 2023
概括
慢性压力增加了肠道的透性和炎症,影响了社会行为. 涉及下丘脑CRH+神经元的特定脑肠回路驱动这些由压力引起的变化,影响肠道健康和情绪.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 重度抑郁症 (MDD) 和易怒肠综合征 (IBS) 与慢性压力有关,但它们在压力期间的脑肠沟通尚不清楚.
- 了解这种双向沟通对于治疗并发性MDD和IBS至关重要.
结论:
- 定义了一种由PVH CRH+神经元产生的新型压力激活的大脑到肠道电路.
- 这个电路驱动结肠炎症,损害肠道屏障功能,并导致与压力相关的行为缺陷.
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