相关实验视频

Updated: Jul 11, 2025

Live Imaging of Mitosis in the Developing Mouse Embryonic Cortex

Live Imaging of Mitosis in the Developing Mouse Embryonic Cortex

Published on: June 4, 2014

在新皮层大小确定和小头的BRN1/2功能

Soraia Barão, Yijun Xu, José P Llongueras

bioRxiv : the preprint server for biology

|November 14, 2023

概括

两种关键的转录因子控制着哺乳动物中新皮层的发育和大脑大小. 它们的失调导致小头,揭示了对大脑进化和疾病的洞察力.

科学领域:

进化生物学是进化的生物学.
神经科学是一个神经科学.
发育生物学是发展生物学.

背景情况:

哺乳动物新皮质的大小和复杂性在物种之间有很大差异.
推动大脑大小增加的进化机制在很大程度上是未知的.

结论:

转录调节对于确定哺乳动物大脑大小至关重要.
这些转录因子的放松调节与小头症的分子病变产生有关.
这些因素的基因操纵导致严重的小头.

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Neurulation

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...