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相关概念视频

Neurulation01:30

Neurulation

42.0K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
42.0K

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Live Imaging of Mitosis in the Developing Mouse Embryonic Cortex
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Live Imaging of Mitosis in the Developing Mouse Embryonic Cortex

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在新皮层大小确定和小头的BRN1/2功能.

Soraia Barão, Yijun Xu, José P Llongueras

    bioRxiv : the preprint server for biology
    |November 14, 2023
    PubMed
    概括

    两种关键的转录因子控制着哺乳动物中新皮层的发育和大脑大小. 它们的失调导致小头,揭示了对大脑进化和疾病的洞察力.

    科学领域:

    • 进化生物学是进化的生物学.
    • 神经科学是一个神经科学.
    • 发育生物学是发展生物学.

    背景情况:

    • 哺乳动物新皮质的大小和复杂性在物种之间有很大差异.
    • 推动大脑大小增加的进化机制在很大程度上是未知的.

    结论:

    • 转录调节对于确定哺乳动物大脑大小至关重要.
    • 这些转录因子的放松调节与小头症的分子病变产生有关.
    • 这些因素的基因操纵导致严重的小头.

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