相关实验视频

Updated: Jul 31, 2026

Chemically-blocked Antibody Microarray for Multiplexed High-throughput Profiling of Specific Protein Glycosylation in Complex Samples
13:21

Chemically-blocked Antibody Microarray for Multiplexed High-throughput Profiling of Specific Protein Glycosylation in Complex Samples

Published on: May 4, 2012

15.8K

克里斯普尔屏幕和莱克微阵列识别了新的高曼诺糖N-甘氨酸调节剂

C Kimberly Tsui1, Nicholas Twells2, Emma Doan1

  • 1Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.

bioRxiv : the preprint server for biology
|November 14, 2023
PubMed
概括

这项研究引入了一种新的方法,将CRISPR屏幕和乳素微阵列结合起来,以识别细胞表面糖化调节剂,特别关注高曼诺斯甘. 研究发现了新的调节剂,通过影响戈尔基形态和功能来控制N-糖化.

更多相关视频

Cell Surface Receptor Identification Using Genome-Scale CRISPR/Cas9 Genetic Screens08:49

Cell Surface Receptor Identification Using Genome-Scale CRISPR/Cas9 Genetic Screens

Published on: June 6, 2020

14.6K
Author Spotlight: MAPP Protocol – Advancing Glycan Analysis07:12

Author Spotlight: MAPP Protocol – Advancing Glycan Analysis

Published on: September 29, 2023

1.8K

相关概念视频

Oligosaccharide Assembly01:24

Oligosaccharide Assembly

Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...