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乳腺癌巨异质性和自我更新是由空间定位决定的

Nir Ben-Chetrit^1,2,3, Xiang Niu^1,2,3,4, Jesus Sotelo^1,2

¹Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.

bioRxiv : the preprint server for biology

|November 14, 2023

概括

瘤透的巨细胞驱动癌症的进展. 准Notch4介导的巨细胞自我更新和空间局部化为乳腺癌和其他恶性瘤提供了一种新的治疗策略.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
细胞生物学细胞生物学

背景情况:

透瘤的巨细胞促进瘤的进展和治疗抵抗.
人们对瘤微环境 (TME) 中巨细胞异质性了解甚少.
了解调节巨细胞积累和功能的信号至关重要.

结论:

空间决定因素在乳腺癌中显著影响巨细胞异质性和功能.
通过Notch4抑制来破坏巨细胞的自我更新是一种有前途的治疗途径.
向巨细胞局部化和自我更新可以克服治疗阻力.

关键词:

乳腺癌乳腺癌乳腺癌巨细胞的自我更新空间转录学空间转录学瘤微环境是一个微环境.与瘤相关的巨细胞.

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