基于安全性,耐受性和可行性的推理和协议,随机,并行组,双盲,安慰剂控制,试点研究一种新的类以免疫代谢老年科学机制为目标的脆弱性
Brianna J Stubbs1, Gabriela Alvarez-Azanedo1, Sawyer Peralta1
1Buck Institute for Research on Aging, Novato, CA, USA.
medRxiv : the preprint server for health sciences
|November 14, 2023
概括
这项试点研究评估了老年人中类 (KEs) 的耐受性和安全性,发现它们对未来关于衰老和脆弱性的研究是可行的.
科学领域:
- 老年学和老年科学是老年学和老年科学.
- 代谢健康与衰老
- 营养生物化学 营养生物化学
背景情况:
- 虚弱是一种与慢性炎症和代谢问题相关的老年综合征,增加了衰老中的脆弱性.
- 针对衰老机制的地质科学干预措施可能会改善脆弱性.
- 体,就像基因 (KEs) 的体一样,正在研究它们的潜在抗衰老作用.
研究的目的:
- 在老年人 (≥65岁) 中,确定12周摄入乙醇 (KE) 的耐受性和安全性.
- 评估急性血动力学,探索对身体功能,认知,生活质量,衰老生物标志物和炎症的影响.
主要方法:
- 一个为期12周的随机,双盲,安慰剂控制的试验试验,涉及30名社区居住的老年人.
- 参与者每天食用25g的KE或安慰剂饮料.
- 评估了耐受性,安全性,动力学,身体/认知功能和生物标志物.
主要成果:
- 该研究评估了KE在老年人中消费的可行性,耐受性和安全性.
- 在各种与地球科学相关的终点上收集了探索性数据.
- 这项试点试验为更大规模的研究提供了基础数据.
结论:
- 在老年人中,摄入类 Ester 似乎是可行的和可以容忍的.
- 这项研究支持对KE的进一步调查,作为治疗脆弱性的基因科学干预措施.
- 这些发现将为对KE在衰老中的有效性进行更大规模试验的设计提供信息.
关键词:
贝塔-基丁酸盐-基丁酸盐外源基是一种外源基.脆弱 脆弱 脆弱 脆弱 脆弱气质科学是地球科学.基二 Ester 是一种基二.类 Ester 是一种类 Ester.子 子 子 子在安全方面,安全是安全的.这是一个宽容的宽容度.更多相关视频
00:04A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
Published on: September 20, 2019
10.7K
06:13Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health
Published on: December 1, 2023
1.1K
相关概念视频
Bioavailability Study Design: Single Versus Multiple Dose Studies
Bioavailability studies are essential for understanding how a drug is absorbed, distributed, metabolized, and excreted in the body. These studies assess the extent and rate at which the active pharmaceutical agent becomes available at the site of action. The design of bioavailability studies can involve single-dose or multiple-dose regimens, each with distinct advantages and limitations.Single-dose studies are the preferred approach due to their simplicity and reduced drug exposure for...
Bioavailability Study Design: Healthy Subjects Versus Patients
Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
