人类细胞中兰氏的表达
Sara M Eslami1, Imran R Rahman2, Wilfred A van der Donk1,2
1Department of Chemistry and Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
bioRxiv : the preprint server for biology
|November 14, 2023
概括
循环,像兰氏一样,由于其稳定性,具有治疗潜力. 这项研究开发了一种系统,用于在哺乳动物细胞中产生和向这些,用于药物发现.
科学领域:
- 生物化学 生物化学
- 分子生物学分子生物学
- 药物发现 药物发现 药物发现
背景情况:
- 循环,包括核糖体合成和翻译后修饰 (RiPPs),是受结构约束和抗蛋白酶的.
- 兰氏RiPP细胞解酶L具有独特的共振稳定螺旋结构.
- 这种结构有可能破坏蛋白质-蛋白质相互作用.
结论:
- 在哺乳动物细胞中实现了兰氏的产生和核向.
- 这个系统可以选蛋白质与蛋白质相互作用的兰氏抑制剂.
- 开辟了循环的治疗应用的道路.
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