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Updated: Jul 11, 2025

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在肺腺癌中,FoxA1/2-依赖的表观基因组重编程驱动了血统切换

Katherine Gillis, Walter A Orellana, Emily Wilson

    bioRxiv : the preprint server for biology
    |November 14, 2023
    PubMed
    概括

    先进的FoxA1/2因子通过改变DNA甲基化和基因调节来将肺癌细胞重新编程为胃的身份,这是一个依赖于瘤性KRAS的过程. 这揭示了在KRAS驱动的肺腺癌中癌细胞谱系切换的机制.

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