人类和 rhesus 的补充介导免疫力的性别和物种相关差异
Natasha S Kelkar1, Benjamin S Goldberg2,3, Jérémy Dufloo4,5
1Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Dartmouth College, Hanover, NH, USA.
bioRxiv : the preprint server for biology
|November 14, 2023
概括
人体补充系统显示出显著的性别差异,与 rhesus macaques 不同. 这项研究揭示了补充活性中的性二态,影响了免疫研究.
科学领域:
- 免疫学 免疫学 免疫学
- 比较免疫学比较免疫学
背景情况:
- 补体系统调节先天性,幽默性和适应性免疫.
- 性和衰老会影响免疫反应,但它们对补充路径的影响还未得到充分研究,特别是在人类和 rhesus macaques 中.
结论:
- 人体补充系统表现出显著的性二态,特别是在功能活动中.
- rhesus 可能不是研究补充通路中的基于性别的差异的理想模型.
- 这些发现扩大了对基于性别的免疫变异及其对研究模型的影响的理解.
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