多巴胺神经元在熟悉性中的作用
Sixtine Fleury1, Rhonda Kolaric1, Justin Espera1
1The Advanced Science Research Center, City University of New York, New York, NY 10031, USA.
bioRxiv : the preprint server for biology
|November 14, 2023
概括
大脑中的多巴胺神经元.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 认知神经科学 认知神经科学
背景情况:
- 众所周知,多巴胺神经元会发出环境刺激的突出信号,影响学习和动机.
- 多巴胺神经元在调节记忆内容突出性的作用仍然在很大程度上未被探索.
- 腹部体区域 (VTA) 的多巴胺神经元活动随着对象的熟悉而下降.
研究的目的:
- 为了研究在熟悉过程中抑制多巴胺神经元活动是否会影响记忆突出性.
- 确定多巴胺神经元活动对新奇性歧视在识别任务中的影响.
- 检查熟悉会话的数量如何影响多巴胺活性和随后的识别记忆.
主要方法:
- 鼠标接受了单次或多次对物体的熟悉会话.
- 使用c-Fos免疫组织化学测量了腹腔体区域 (VTA) 多巴胺神经元激活.
- 在熟悉过程中使用了VTA多巴胺神经元的化学遗传抑制.
- 新型对象识别 (NOR) 测试被用来评估新性歧视.
主要成果:
- 与单个会话相比,多次熟悉会话导致VTA多巴胺神经元激活率降低.
- 在NOR测试中,经过多次熟悉会话的小鼠显示出增强的新奇性歧视.
- 在一次熟悉会话中抑制VTA多巴胺神经元改善了NOR的性能.
- 这些结果表明多巴胺神经元活动与记忆突出性和新奇性歧视相反相关.
结论:
- 多巴胺神经元在处理熟悉方面发挥着至关重要的作用.
- 在熟悉过程中减少多巴胺神经元活动,增强了新奇的突出性.
- 多巴胺神经元调节记忆内容的突出性,影响识别记忆.
- 向多巴胺神经元活动可能提供增强记忆和识别的策略.
相关概念视频
Physiology of Smell and Olfactory Pathway
8.6K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
The olfactory...
8.6K
Role of Neurotransmitters in Memory
583
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
583
Role of Amygdala in Memory
249
The amygdala is a small, almond-shaped structure responsible for processing and storing memories, particularly those linked to emotions like fear and stress. It plays an essential role in the brain's response to emotionally significant events and often enhances memory formation by triggering stress hormone release. The amygdala is vital for encoding and retrieving memories associated with fear or stress, a process that is adaptive by helping organisms avoid dangerous situations.
One of the...
One of the...
249
Diencephalon: Thalamus and Information Relay
1.6K
The thalamus, often called “the gateway to the cerebral cortex,” is vital in processing and directing sensory and motor signals throughout the brain. Almost all inputs destined for the cerebral cortex, except for olfactory signals, are relayed through the thalamus. The thalamus is a sophisticated relay station, channeling information from various brain regions to the cerebral cortex, as well as a filter, prioritizing certain signals over others based on current physiological...
1.6K
Nonconscious Mimicry
4.6K
Nonconscious mimicry occurs when individuals alter their mannerisms to match the behaviors and expressions of those nearby, without intention.
4.6K
Olfaction
44.4K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
The olfactory receptors are embedded in the cilia of the...
44.4K


