由原型疫苗诱导的免疫球蛋白和T细胞受体谱的变化,针对Chagas病的原始 rhesus macaques
Eric Dumonteil1, Weihong Tu1, Hans Desale1
1Tulane University.
Research square
|November 14, 2023
概括
对查加斯病 (由Trypanosoma cruzi引起) 的新疫苗显示出有希望. 转录基因分析显示,三次剂量引起了的强烈免疫反应,表明了最佳的免疫性.
科学领域:
- 免疫学 免疫学 免疫学
- 寄生虫学的寄生虫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 查加斯病是由Trypanosoma cruzi引起的,对公众健康构成重大挑战.
- 一种针对Tc24和TSA1抗原的复合疫苗在临床前模型中证明了安全性和免疫性.
- 了解免疫应对疫苗接种对于优化疫苗疗效至关重要.
结论:
- 研究结果表明,对于这种查加斯病疫苗的最佳免疫性,需要三剂.
- 观察到的免疫反应概况支持进一步研究疫苗的保护效果.
- 这项研究为优化用于控制查加斯病的疫苗配方和剂量提供了宝贵的见解.
更多相关视频
相关概念视频
Cells of the Adaptive Immune Response
999
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
999
Diversity of Antigen Receptors
599
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
599
T Cell Activation and Clonal Selection
753
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
753
Vaccinations
44.6K
Overview
44.6K
Cross-reactivity
31.2K
Overview
31.2K
Antigens Involved in Adaptive Immunity
507
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
Complete Antigens
Complete antigens possess both immunogenicity and...
507


