肌源性人工物伪装成神经可塑性在听觉频率跟踪响应 (FFR) 中
bioRxiv : the preprint server for biology
|November 14, 2023
概括
频率跟踪响应 (FFR) 可能受到肌肉活动的显著污染,而不仅仅是大脑信号. 这种脑后肌肉人工物挑战了当前关于FFR在听觉处理和神经可塑性方面的理解.
科学领域:
- 听觉神经科学 听觉神经科学
- 神经生理学 神经生理学
背景情况:
- 频率跟踪响应 (FFR) 是一个反映听觉处理的神经信号.
- FFR用于研究语音,音乐,神经可塑性和听力/语言障碍.
- 人们普遍认为FFRs仅来自听觉通路中的神经活动.
研究的目的:
- 调查潜在的非神经对FFR的贡献.
- 挑战目前普遍认为FFRs仅仅是神经性.
主要方法:
- 在人类参与者中测量FFR.
- 评估脑后肌肉 (PAM) 活动对FFRs的影响.
- 通过眼睛的凝视方向实验性地操纵PAM收缩.
主要成果:
- 高达~50%的FFR信号可能来自PAM人工物.
- 在所有参与者身上都存在PAM人工物,并受到电极放置的影响.
- PAM收缩可以将FFR放大3-4倍,模仿神经可塑性效应.
结论:
- 一个重要的肌源性 (肌肉产生的) 源污染了FFR.
- 这种PAM人工物有助于FFR主体间的变化.
- 与神经可塑性或病理相关的归因FFR变化可能部分或全部是肌源性.
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