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白质过强度会改变皮质脊柱管损伤和中风后运动结果之间的关系

Jennifer K Ferris^1,2, Bethany P Lo³, Giuseppe Barisano⁴

¹Gerontology Research Centre, Simon Fraser University, Vancouver, British Columbia, Canada.

medRxiv : the preprint server for health sciences

|November 14, 2023

概括

白质强度过高 (WMHs) 会使中风后的运动障碍恶化,特别是当皮质脊髓 (CST) 损伤轻微时. 中度至严重的WMH独立预测运动缺陷,突出显示大脑结构储备的重要性.

科学领域:

神经科学是一个神经科学.
神经学神经学
放射学放射学是一门学科.

背景情况:

脑卒中后的运动结果与皮质脊柱管 (CST) 损伤有关.
白质超强度 (WMHs) 可能会影响中枢神经系统损伤后的恢复能力.

研究的目的:

调查WMH是否调节CST损伤和中风后运动损伤之间的关联.
探索WMH严重程度对运动恢复的影响.

主要方法:

利用了223人 (ENIGMA中风恢复工作组) 的数据.
使用加权的 CST 损伤负荷 (CST-LL) 进行索引的 CST 损伤.
采用混合效应β回归模型来分析CST-LL,WMH体积,以及它们对运动障碍的相互作用.

主要成果:

独立预测的WMH体积运动障碍 (β = 0.178,p = 0.022).
在轻微的WMH病例中,运动障碍与CST-LL相关 (β = 0.888,p < 0.001),具有显著的相互作用 (β = -0.211,0.026).
在中度至严重的WMH病例中,运动障碍与WMH体积有关 (β = 0.299,p = 0.044) 但与CST-LL无关.

结论:

与WMH相关的损伤是中风后运动结果变化的重要,潜在的未被认可的因素.
大脑结构储备,由WMH负担表示,对于脑损伤后的运动恢复至关重要.

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