哺乳动物的昼夜钟蛋白质形成动态相互作用的微体,与相位分离有所区别
Pancheng Xie1,2, Xiaowen Xie1, Congrong Ye1
1Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
bioRxiv : the preprint server for biology
|November 14, 2023
概括
生物钟中液体-液体相分离 (LLPS) 的生理相关性尚不清楚. 内生PERIOD蛋白质形成不同的微体,而不是LLPS凝聚物,这表明在哺乳动物昼夜反循环中具有类似酶的作用.
科学领域:
- 细胞生物学 细胞生物学
- 时间生物学 时间生物学
- 生物物理学的生物物理.
背景情况:
- 液-液相分离 (LLPS) 对生物过程至关重要,但其在昼夜节律中的生理相关性仍然不确定.
- 核心时钟蛋白,包括PERIOD (PER) 蛋白,在哺乳动物的昼夜负反循环中形成复合体.
结论:
- 内生PER2微体与LLPS凝结物因过度表达而引起的显著不同.
- 核心时钟蛋白的动态,短暂的相互作用表明,在昼夜调节中存在类似酶的机制.
- 研究内源性蛋白质对于理解LLPS和昼夜钟机制至关重要.
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