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在患有唐氏综合征的成年人中,连接脉冲压与痴呆的途径
Batool Rizvi1,2, Patrick J Lao3,4,5, Mithra Sathishkumar1,2
1Center for the Neurobiology of Learning and Memory, University of California, Irvine, CA.
medRxiv : the preprint server for health sciences
|November 14, 2023
概括
较高的脉压,血流的度量,与患有唐氏综合征 (DS) 的成年人痴呆症风险增加有关. 这种风险是由脑血管疾病和神经退行症介导的,这会影响这个人群中的大脑健康.
科学领域:
- 神经学 神经学
- 心血管健康 心血管健康
- 遗传学 遗传学 是一个
背景情况:
- 唐氏综合征 (DS) 患者的高血压率较低,但他们的脑血管健康需要进一步研究.
- 在DS中血压,大脑结构和痴呆症之间的关系尚未得到充分理解.
研究的目的:
- 调查脉冲压与脑血管疾病标志物,脑缩和唐氏综合征成人痴呆症诊断之间的关联.
- 探索在DS患者中将脉冲压与痴呆症联系起来的潜在途径.
主要方法:
- 利用了阿尔茨海默病生物标志物在唐氏综合征 (ADDS) 的成年人研究的数据 (n=195).
- 估计的脉压,白质超强度 (WMH) 体积,周血管空间 (PVS) 扩大,微型血流,心脏病发作和内腔皮层厚度.
- 采用串行调解分析来模拟脉冲压,WMH,内腔厚度和痴呆症诊断之间的关系.
主要成果:
- 较高的脉压与增加的全球,头顶和尾白质过强度 (WMH) 体积相关.
- 脉压与扩大的PVS,微型血流,心脏病发作或内皮层厚度之间没有直接联系.
- 脉压与痴呆症诊断间接相关,其介导的是腰尾WMH和内皮层厚度.
结论:
- 脉压升高可能是唐氏综合征患者痴呆症的危险因素.
- 脑血管疾病 (WMH) 和随后的神经退行 (神经退行) 显现为脑内皮层稀释,这似乎是关键的途径.
- 脉压是影响大脑健康和老年痴呆症风险的重要因素,无论整体高血压的流行程度如何.
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