视力障碍细胞非自主地调节大脑全方位的蛋白质稳定
Shashank Shekhar1, Katherine J Wert2,3, Helmut Krämer1,3,4
1Department of Neuroscience, UT Southwestern Medical Center; Dallas, TX.
bioRxiv : the preprint server for biology
|November 14, 2023
概括
视力或听力损失与痴呆症风险有关. 感官剥夺会触发大脑的压力颗粒,影响蛋白质质量控制,但这是可逆的.
科学领域:
- 神经科学是一个神经科学.
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 听力和视力损失是痴呆症风险因素,但分子联系仍然不清楚.
- 细胞应激反应,特别是蛋白质质量控制,对于大脑健康至关重要.
结论:
- 感官输入损失失调节大脑应激反应,影响蛋白质质量控制.
- 感官剥夺和改变的压力颗粒动态之间的联系在物种之间得到保护.
- 这些发现提供了关于连接感官缺陷和痴呆风险的分子机制的见解.
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