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Updated: Jul 11, 2025

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设计高效的人工酶,使用晶体学增强的 conformational 采样

Rojo V Rakotoharisoa1,2, Behnoush Seifinoferest3, Niayesh Zarifi1,2

  • 1Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario, Canada, K1N 6N5.

bioRxiv : the preprint server for biology
|November 14, 2023
PubMed
概括

计算设计通过分析蛋白质灵活性来创建高效的人工酶. 这种方法绕过了传统的定向进化,实现了与自然酶相比的催化改进.

关键词:
一个新的酶设计设计.坎普消除了这些问题.在X射线晶体学.生物催化剂的生物催化剂指导进化是指导进化的.整体提炼 整体提炼

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相关概念视频

Catalytically Perfect Enzymes01:07

Catalytically Perfect Enzymes

The theory of catalytically perfect enzymes was first proposed by W.J. Albery and J. R. Knowles in 1976. These enzymes catalyze biochemical reactions at high-speed. Their catalytic efficiency values range from 108-109 M-1s-1. These enzymes are also called 'diffusion-controlled' as the only rate-limiting step in the catalysis is that of the substrate diffusion into the active site. Examples include triose phosphate isomerase, fumarase, and superoxide dismutase.
 
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