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在熟练的运动序列中进行行动协调的皮质 - thalamic通信
Yi Li1,2, Xu An1,2, Patrick J Mulcahey1
1Department of Neurobiology, Duke University, Durham, NC 27710, USA.
bioRxiv : the preprint server for biology
|November 14, 2023
概括
研究人员发现了一个关键的大脑电路协调饮酒运动. 来自运动皮层的皮质体内道选择性地增强了体内活动,使得像伸手和喝水这样的熟练运动序列成为可能.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 系统神经科学 系统神经科学
背景情况:
- 在食时协调前肢和面部运动至关重要.
- 跨大脑区域的神经通信是复杂行为的基础,比如达到消费.
研究的目的:
- 为了确定皮质网络协调鼠标的触及和吸收饮料 (RWD) 行为中的动作进展.
- 研究二级运动皮层 (MOs-c) 中不同类型的投射神经元和输出通道的作用.
主要方法:
- 广场成像和光抑制在整个皮质.
- 电生理学和向的光抑制投射神经元类型在MO-c.
- 在小鼠的RWD行为期间神经活动的分析.
主要成果:
- 确定了一个特定的皮质网络,包括MOs-c,用于RWD行为协调.
- 皮质othalamic (CTMOs) 输出通道,但不是金字塔管道通道,显示持续发射和选择性增强thalamic活动.
- CTMOs神经元接收收的感觉运动输入,并与参与行动协调的乳头神经元相互作用.
结论:
- 运动皮层的皮质体内管在协调熟练的运动序列方面发挥着至关重要的作用.
- 这个通道可以放大感应运动信息的thalamic集成,以精确控制动作.
- 了解这种电路可以了解复杂的运动行为的神经基础.
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