病理性关节活动驱动人类慢性疼痛中的异常认知网络处理.
Brent W Stewart1, Michael L Keaser1, Hwiyoung Lee2
1Department of Neural and Pain Sciences, University of Maryland School of Dentistry, Baltimore, MD, USA.
bioRxiv : the preprint server for biology
|November 14, 2023
概括
关节,一个大脑区域,在疼痛期间活跃,在偏头痛患者中显示异常功能,可能导致认知问题. 这项研究揭示了与慢性疼痛和认知缺陷有关的新脑电路.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 疼痛研究 疼痛研究
背景情况:
- 慢性疼痛与认知网络功能障碍有关.
- 与疼痛相关的认知缺陷有关的确切机制和大脑区域尚不清楚.
- 关闭体在认知网络调制中的作用需要进一步研究.
研究的目的:
- 研究关闭层在急性疼痛处理和认知网络调制中的作用.
- 在慢性疼痛患者 (偏头痛) 中识别闭膜活动及其网络连接的变化.
- 阐明在慢性疼痛中潜在的认知障碍的神经电路机制.
主要方法:
- 功能性脑成像 (fMRI) 来评估疼痛期间的关闭活动和健康个体的预测性暗示暴露.
- 分析偏头痛患者的关闭层和前额叶皮层活动.
- 动态因果建模 (DCM) 来推断大脑区域之间的定向连接.
- 扩散权重成像 (DWI) 来评估结构连接.
主要成果:
- 在健康参与者中,关节被急性疼痛刺激和疼痛预测线索激活.
- 偏头痛患者在关闭层和右背侧前额皮层 (latDLPFC) 的侧面方面表现出病态活动.
- DCM分析表明,关闭空间对LatDLPFC活动有着定向的影响,这得到了DWI对结构连接性的研究结果的支持.
结论:
- 闭关体在急性疼痛期间起到调节认知网络的作用.
- 异常的claustrum-latDLPFC电路活动和连接性可能是偏头痛等慢性疼痛疾病的认知缺陷的基础.
- 这些发现突出了慢性疼痛中认知障碍的潜在神经基质.
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