药物地图:对氨酸结合性的定量泛癌分析
bioRxiv : the preprint server for biology
|November 14, 2023
概括
由于细胞差异,癌症中的氨酸向因细胞差异而有所不同. 新的共价探头准NFκB1和SOX10转录因子,破坏癌症信号通路.
科学领域:
- 化学生物学是化学生物学.
- 蛋白质组学是指蛋白质组学.
- 癌症研究 癌症研究
背景情况:
- 针对癌症标的共价抑制剂正在推进.
- 了解癌症背景如何影响囊蛋白向是至关重要的.
结论:
- 半氨酸的结合性在癌症中显示出异质性.
- 细胞内在的特征驱动着囊蛋白的向.
- 共价探头可以破坏瘤转录因子活性.
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