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在形态发生过程中,生长对与组织属性的时间和空间波动相结合

Antoine Fruleux¹, Lilan Hong², Adrienne H K Roeder³

¹RDP, Université de Lyon, ENS de Lyon, UCB Lyon 1, INRAE, CNRS, 69364 Lyon Cedex 07, France LadHyX, CNRS, Ecole polytechnique, Institut Polytechnique de Paris, 91128 Palaiseau Cedex, France and LPTMS, CNRS, Université Paris-Saclay, 91405, Orsay, France.

bioRxiv : the preprint server for biology

|November 14, 2023

概括

活体组织表现出与生长相结合的波动,揭示了空间和时间变化的远程相关性. 这种生长机制被称为"波动拉伸",影响组织发育和强度.

科学领域:

* 发育生物学发育生物学
* 生物物理生物物理
* 量化生物学 * 量化生物学

背景情况:

* 活体组织在多个尺度上表现出时空波动,可能与感知组织状态或大小有关.
* 理论模型预测在发育中的组织中生长波动的长期相关性.
* 了解这些波动是理解组织形态发生和强度的关键.

研究的目的:

* 调查和验证组织生长波动中长距离相关性的理论预测.
* 介绍组织性质波动的时间持久性的最小模型.
* 探索生长过程中的时间和空间波动之间的合机制,称为"波动拉伸".

主要方法:

* 开发了具有时间持久性的波动的最小理论模型.
*使用细胞里埃转换分析了Arabidopsis体的实验生长数据.
*比较了不同基因型和生长条件的波动特征,包括机械应激反应突变.

主要成果:

* 确认了具有时间记忆的数量在时空波动中的通用远程相关性.
* 证明增长通过"波动拉伸",扩大变化长度尺度,结合时间和空间波动.
*观察到,与野生类型植物相比,Arabidopsis*突变体表现出改变的时间和空间相关性模式.

结论:

*生长本质上与时间和空间的波动相结合,影响形态发生.
* 对时空波动的动态约束对于组织发育的强度至关重要.
*这些发现为了解各种疾病中的组织波动提供了一个统一的框架.

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