细胞规则是前额头金字塔神经元的迷幻控制的基础
Tyler G Ekins1,2, Isla Brooks1, Sameer Kailasa3
1Dept. of Psychology, University of Michigan, Ann Arbor, MI 48109.
bioRxiv : the preprint server for biology
|November 14, 2023
概括
迷幻药物,与普遍认为的相反,通过增强M电流通道来抑制大脑细胞兴奋能力. 这种新的机制,独立于血清素受体,可以解释它们的治疗作用.
科学领域:
- 神经科学是一个神经科学.
- 心理药理学 心理药理学
- 计算生物学 计算生物学
背景情况:
- 经典的迷幻药被认为可以通过血清素2A受体 (5-HT2AR) 增强前额叶皮质金字塔细胞刺激能力.
- 迷幻药物作用的精确机制,特别是它们对神经元刺激性的影响,仍然不完全理解.
结论:
- 迷幻药物通过一种涉及M电流通道增强的新机制抑制神经元内在刺激能力.
- 这种离子通道调节在整个大脑中无处不在,独立于5-HT2AR.
- 这些发现表明,迷幻药可能会触发恒常调整,有助于其广泛的治疗潜力.
更多相关视频
相关概念视频
CNS Stimulants: Psychedelic Agents
158
Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
158
Hallucinogens and Psychedelics
179
Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
179
Neurochemical Transmission: Sites of Drug Action
2.4K
Neurochemical transmission, the conduction of electrical impulses between neurons mediated by neurotransmitters, plays a vital role in various physiological processes. Autonomic drugs exert their effects by modulating neurotransmission within the autonomic nervous system. For instance, drugs such as hemicholinium block the precursor uptake necessary for synthesizing acetylcholine, an essential autonomic neurotransmitter. Following synthesis, neurotransmitters are stored in vesicles. Metyrosine...
2.4K


