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Updated: Jul 30, 2026

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在康复的COVID-19患者中减少单细胞比例和反应能力

Eugene V Ravkov, Elizabeth S C P Williams, Mark Elgort

    bioRxiv : the preprint server for biology
    |November 14, 2023
    PubMed
    概括

    COVID-19感染改变了免疫细胞平衡,减少了特定的单细胞类型. 这些免疫变化,包括激活和细胞因子产生减少,即使在严重急性呼吸系统综合征冠状病毒2型 (SARS-CoV-2) 恢复后也会持续存在.

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    Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...