临床和人口因素改变了血酸化tau-181与认知之间的关联
medRxiv : the preprint server for health sciences
|November 14, 2023
概括
血酸化tau181 (p-tau181) 与多个领域的认知功能差异有关. 这些关联因阿尔茨海默病的阶段,APOE ε4状态,年龄和性别而异.
科学领域:
- 神经科学是一个神经科学.
- 生物标志物 生物标志物
- 阿尔茨海默氏症疾病研究研究
背景情况:
- 血酸化tau181 (p-tau181) 是已知的阿尔茨海默病 (AD) 的生物标志物.
- 之前的研究已经确定了p-tau181与全球认知/记忆之间的联系.
- p-tau181与其他认知领域,主观认知衰退 (SCD) 和影响因素之间的关系仍然不清楚.
研究的目的:
- 研究血p-tau181水平与各种认知领域之间的关联.
- 探索血p-tau181与主观认知衰退 (SCD) 之间的关系.
- 检查遗传 (APOE ε4),人口 (年龄,性别) 和疾病因素如何改变这些关联.
主要方法:
- 来自阿尔茨海默病神经成像计划的1185名成年人 (>55岁) 的数据分析.
- 使用的血p-tau181水平和综合的神经心理测试数据.
- 采用线性回归模型来评估与认知诊断的关联和相互作用,APOE ε4状态,年龄和性别.
主要成果:
- 较高的血p-tau181与更差的记忆,执行功能和语言表现相关.
- 更多的告知者报告的SCD与更高的血p-tau181.1.相关.
- 对于视觉空间能力或自我报告的SCD,没有发现有意义的关联.
- 在患有轻度认知障碍 (MCI) 或痴呆症,APOE ε4携带者,女性和年轻参与者中,相关性更为明显.
结论:
- 血p-tau181升高与多个领域的认知功能受损有关.
- 这些关联的强度受阿尔茨海默氏症疾病阶段,APOE ε4载体状态,年龄和性别的影响.
- 血p-tau181作为一个有价值的生物标志物,反映了阿尔茨海默氏症的认知状态,在不同人群中存在微妙的关系.
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