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Updated: Jul 11, 2025

Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations
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Author Spotlight: An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell Populations

Published on: April 21, 2023

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网络回归嵌入揭示了基因调节的细胞类型转录因子协调

Saniya Khullar, Xiang Huang, Raghu Ramesh

    bioRxiv : the preprint server for biology
    |November 14, 2023
    PubMed
    概括

    我们开发了NetREm,一个计算工具,以了解转录因子 (TF) 协调如何调节不同细胞类型的目标基因 (TG). 该方法确定了新的TF-TF协调链接及其在基因调节中的作用,并通过实验数据验证.

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    Published on: June 15, 2016

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    相关概念视频

    General Transcription Factors01:30

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    Transcription Factors02:16

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    Proteins that regulate transcription can do so either via direct contact with RNA Polymerase or through indirect interactions facilitated by adaptors, mediators, histone-modifying proteins, and nucleosome remodelers. Direct interactions to activate transcription is seen in bacteria as well as in some eukaryotic genes. In these cases, upstream activation sequences are adjacent to the promoters, and the activator proteins interact directly with the transcriptional machinery. For example, in...
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