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Updated: Oct 20, 2026

The Tail Suspension Test
10:17

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Published on: January 28, 2012

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慢性治疗对神经元刺激性和GABAergic传递在Ank3突变小鼠模型中的影响

René N Caballero-Florán1, Andrew D Nelson2, Lia Min1

  • 1Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109.

bioRxiv : the preprint server for biology
|November 14, 2023
PubMed
概括

治疗通过增强抑制信号来使双相情感障碍 (BD) 的小鼠模型中的大脑活动正常化. 这一发现为BD和相关的精神疾病提供了新的治疗途径.

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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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