显著的肠道微生物特征与艾滋病毒感染者的加速生物衰老有关
Shalini Singh1, Leila B Giron1, Maliha W Shaikh2
1The Wistar Institute.
Research square
|November 14, 2023
概括
接受抗逆转录病毒疗法 (ART) 的艾滋病毒感染者 (PWH) 在肠道和血液中由于微生物失调和转移而表现出加速的生物衰老. 这将肠道健康与PWH的衰老和炎症联系在一起.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 衰老研究研究 衰老研究
背景情况:
- 艾滋病毒感染者 (PWH),即使在有效的抗逆转录病毒疗法 (ART) 上,也会经历持续的炎症.
- 这种炎症与肠道微生物失衡 (失生症) 和微生物转移有关,可能导致非艾滋病相关的老化并发症.
- 关于艾滋病毒对肠道生物年龄的影响以及肠道微生物组变化在ART上的PWH中的作用存在不确定性.
研究的目的:
- 为了调查艾滋病毒感染是否加快了在ART患者的肠道和血液中的生物衰老.
- 确定微生物失调和转移是否有助于在ART上的PWH加速生物衰老.
- 探索特定的肠道微生物,代谢物和在ART上的PWH中的生物衰老之间的关系.
主要方法:
- 使用了系统生物学方法,分析了结肠和胆管活检,血液和便样本.
- 用表观遗传衰老时钟来评估不同组织的生物年龄.
- 分析了微生物组成,蛋白质含量和代谢物概况.
主要成果:
- 与艾滋病毒阴性对照组相比,在ART治疗中的PWH在结肠,大肠和血液中表现出加速的生物衰老,尽管时间表年龄相似.
- 在接受ART的PWH中观察到微生物转位的增加和紧结蛋白的减少,与更快的生物衰老和炎症相关.
- 特定的促炎性肠道细菌 (例如, *Catenibacterium*, *Prevotella*) 丰富,与加速衰老有关,而有益的细菌 (例如, *Subdoligranulum*) 减少.
- 相关性网络突出显示了肠道微生物种类,促炎代谢物和在ART上的PWH中加速衰老之间的联系.
结论:
- 在ART上的PWH中,独特的微生物组成和相关的代谢途径与肠道和全身生物衰老相互联系.
- 这些发现确定了推动PWH过早衰老的潜在机制.
- 了解这些微生物组与衰老的联系可能会导致策略来缓解PWH中与衰老相关的并发症.
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