在产前饥荒暴露后60年加速的生物衰老
Mengling Cheng1,2, Dalton Conley3, Tom Kuipers4
1Swiss Centre of Expertise in Life Course Research, University of Lausanne, Lausanne, Switzerland.
medRxiv : the preprint server for health sciences
|November 14, 2023
概括
早期的饥饿暴露加速了生物衰老,特别是在女性身上. 这项研究使用表观遗传钟来测量荷兰饥饿冬季幸存者的衰老,发现更快的衰老率与产前营养不良有关.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 发展生物学 发展生物学
- 老年学是指老年学的学科.
背景情况:
- 假设早期的逆境加速了生物衰老.
- 荷兰饥饿冬季家庭研究 (DHWFS) 提供了一个独特的自然实验来调查这一假设.
- 产前暴露于饥荒条件提供了一种特殊的早期生活逆境形式.
结论:
- 在荷兰饥饿冬季的子宫内营养不良与晚年加速的生物衰老有关.
- 这些发现凸显了早期环境侮辱对衰老轨迹的长期影响.
- 表观遗传钟为评估发育逆境的生物后果提供了有价值的工具.
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