哪些冠状动脉疾病患者应该将口服酸盐列入他们的出院药物清单?
Chen Xueying1,2, Zhang Hua3, Zhao Lujing1
1Department of Cardiology, Jining Key Laboratory for Diagnosis and Treatment of Cardiovascular Diseases, Affiliated Hospital of Jining Medical University, Jining, Shandong, China.
Acta cardiologica
|November 14, 2023
概括
口服酸盐在排出时与冠状动脉疾病 (CAD) 患者的主要不良心血管事件 (MACE) 不相关. 然而,酸盐在高血压患者中增加了MACE,并且可能是尿酸低的患者.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 冠状动脉疾病 (CAD) 管理包括优化排泄药物.
- 口服酸盐在冠状动脉血管造影 (CAG) 后预防主要不良心血管事件 (MACE) 的作用需要澄清.
研究的目的:
- 为了研究口服酸盐在放出药物和MACEs在CAD患者之间的关联.
- 确定口服酸盐可能影响CAG后MACE的患者子组.
主要方法:
- 对2979名CAD患者进行了回顾性队列研究.
- 对MACE的随访时间平均为4.42年.
- 采用多变量Cox比例危险和分层分析.
主要成果:
- 在CAD患者的口服酸盐和MACE之间没有发现整体关联 (p > 0.05).
- 在口服酸盐的高血压患者中,MACE的发生率显著增加 (HR: 1.67,p = 0.0046).
- 在服用口服酸盐时尿酸水平较低的患者中观察到MACE增加的趋势 (HR: 1.44, p = 0.0525).
结论:
- 排放时的口服酸盐与一般CAD人群中的MACE无关.
- 同时的高血压或低尿酸水平可能会改变CAD患者口服酸盐相关的风险.
- 在给特定的CAD患者亚组开口酸盐时,建议仔细考虑和监测.
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