在日本实施性别中立HPV疫苗的健康影响和成本效益
Cody Palmer1, Keisuke Tobe2, Yusuke Negishi2
1Biostatistics & Research Decision Sciences, Merck & Co., Inc, Rahway, NJ, USA.
Journal of medical economics
|November 14, 2023
概括
在日本,针对人类乳头瘤病毒 (HPV) 的性别中立疫苗接种 (GNV) 比仅针对女性的疫苗接种 (FOV) 预防了更多的癌症和死亡. 农用疫苗具有成本效益,特别是女性疫苗接种覆盖率较低.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 卫生经济学 卫生经济学
背景情况:
- 人类乳头瘤病毒 (HPV) 疫苗接种策略对于预防疾病至关重要.
- 评估不同疫苗接种方法的成本效益对于公共卫生政策至关重要.
研究的目的:
- 为了比较性别中立疫苗 (GNV) 对日本HPV的公共卫生影响和成本效益,与仅针对女性的疫苗 (FOV) 相比.
- 模拟这些疫苗接种策略在100年内的长期影响.
主要方法:
- 为了评估公共卫生影响和成本效益,进行了一项建模研究.
- 使用单向灵敏度分析和场景分析来评估参数和覆盖率变化.
主要成果:
- 与FOV相比,GNV在女性和男性中避免了显著更多的癌症病例和死亡.
- 格纳维尔证明了每增加的质量调整后寿命年增加的4,732,320日元 (35,987美元) 的增量成本效益比.
- 该模型对折扣率和疾病不实用性的敏感性最高;GNV在较低的女性疫苗接种覆盖率下显示出更大的好处.
结论:
- 预计在日本实施GNV将减少与HPV相关的疾病负担和死亡率.
- 与FOV相比,GNV是一种具有成本效益的策略,特别是如果女性接种疫苗的覆盖率保持在30%.
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