增长激素,动脉样硬化和周围动脉疾病:探索从巨病到增长激素缺乏症的频谱
R Herman1,2, A Janez1,2, D P Mikhailidis3
1Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Current vascular pharmacology
|November 14, 2023
概括
增长激素 (GH) 和类似胰岛素的增长因子1 (IGF-1) 轴对心血管健康至关重要. 这个轴上的不平衡会增加心血管疾病的风险,但管理这些疾病会改善结果.
科学领域:
- 心血管生理学心血管生理学
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
背景情况:
- 增长激素 (GH) 和类似胰岛素的增长因子1 (IGF-1) 轴对心血管系统的发育和功能至关重要.
- GH和IGF-1通过复杂的分子网络调节心脏和内皮结构和功能.
- 升高的GH水平与心血管死亡率相关,即使在没有明显GH-IGF-1轴功能障碍的个体中也是如此.
研究的目的:
- 审查GH-IGF-1轴在心血管系统功能中的关键作用.
- 探索GH-IGF-1轴障碍对心血管疾病发病率和死亡率的影响.
- 为了检查GH-IGF-1轴功能障碍和动脉样硬化之间的关系.
主要方法:
- 对GH-IGF-1轴和心血管健康研究的文献综述.
- 对心血管死亡率和发病率在GH过量和缺乏状态下的数据的分析.
- 检查伴随性疾病对GH-IGF-1轴障碍中的心血管风险的影响.
主要成果:
- GH-IGF-1轴的病理状况 (过量或不足) 与心血管发病率和死亡率的增加有关.
- 在GH-IGF-1轴疾病中的疾病控制改善了心血管风险因素并降低了死亡率.
- 有限的数据存在于周围动脉疾病的患病率和GH/IGF-1在壮症和GH缺乏症的影响.
结论:
- GH-IGF-1轴显著影响心血管健康和疾病.
- 在GH-IGF-1轴中的干扰会导致心血管并发症,包括动脉样硬化.
- 有效管理GH-IGF-1轴障碍导致改善心血管结果.
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