心力衰竭与保存的喷射分数风险与阻塞性睡眠呼吸暂停的患病率和严重程度有关
John E Connolly1, Michael V Genuardi2, Jorge I Mora3
1Department of Internal Medicine, Johns Hopkins Hospital, Baltimore, Maryland.
概括
高的H2FPEF得分与阻塞性睡眠呼吸暂停 (OSA) 的患病率和严重程度有很强的相关性. 然而,这种关联主要是由肥胖引起的,这表明需要在OSA患者中进行心脏工作,并在HFpEF患者中进行睡眠研究.
科学领域:
- 心脏病学 心脏病学
- 睡眠医学 睡眠医学
- 内部医学 内部医学
背景情况:
- 在阻塞性睡眠呼吸暂停 (OSA) 患者中,经常观察到心力衰竭与保存的喷射分数 (HFpEF).
- 预测HFpEF风险的评分系统,如H2FPEF和HFA-PEFF,尚未在OSA患病率和严重程度方面进行广泛研究.
研究的目的:
- 调查HFpEF风险评分系统 (H2FPEF) 与OSA的流行率和严重程度之间的关联.
- 为了检查心声回声学标记器的腹功能障碍和OSA严重程度之间的关系.
主要方法:
- 对277名患者进行了回顾性图表审查,这些患者接受了心声回声和睡眠研究.
- 使用趋势和逻辑回归的线性测试来分析回声心脏学参数,H2FPEF得分以及OSA的严重程度和患病率之间的关联.
主要成果:
- OSA的严重程度与左心房体积指数和左心室相对厚度等心声学标记相关.
- 患有高H2FPEF评分的患者表现出明显更高的OSA流行概率 (超过17倍的增加).
- H2FPEF得分与OSA严重程度有很强的相关性,但在控制身体质量指数后,这种关联减少了.
结论:
- 扩张性功能障碍标志物与 ambulatory 患者群体中的 OSA 严重程度有关.
- 虽然H2FPEF得分与OSA有关,但肥胖在很大程度上解释了这种关系.
- 临床医生应考虑对OSA患者进行心脏评估,对HFpEF患者进行睡眠研究.
更多相关视频
相关概念视频
01:21Sleep Apnea
161
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
161
01:17Pathophysiology of Heart Failure
1.6K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.6K
01:22Heart Failure VI: Adjunct Therapies
15
Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
15
01:27Heart Failure I: Introduction
14
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
14
01:30Heart Failure IV: Classification and Diagnostic Evaluation
17
Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
17
01:26Heart Failure III: Clinical Manifestations
20
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
20