对非头部和部皮肤状细胞癌的分期系统的性能
Ricardo Guerra1, Kathryn T Shahwan1,2, Melica Nikahd3
1The Ohio State University Medical Center Department of Dermatology, Columbus, Ohio.
概括
目前的分期系统有效地预测了非头部和部皮肤状细胞癌的不良结果. 这项研究验证了美国癌症联合委员会第八版和布里格姆妇女医院对这些瘤的分期系统.
科学领域:
- 皮肤病学 皮肤病学
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 目前用于非头皮肤状细胞癌的分期系统的有效性仍未得到充分研究.
- 准确的分期对于预测患者的结果和指导治疗决策至关重要.
研究的目的:
- 评估美国癌症联合委员会 (AJCC) 第八版分期系统的表现.
- 评估布里格姆和妇女医院 (BWH) 阶段系统的实用性.
- 确定这些系统对非头部和部皮肤状细胞癌的预测价值.
主要方法:
- 追溯分析了1,042个初级皮肤状细胞癌瘤.
- 应用AJCC第八版和BWH分阶段系统.
- 区别性,灵敏性,特异性,预测值和一致性指数的计算.
主要成果:
- 高阶段瘤 (2.2-3.5%) 与不成比例地更高的不良结果率 (26.3%) 和主要不良结果率 (50%) 相关.
- 对于预测主要的不良结果,BWH系统的灵敏度为0.5,特异性为0.99.
- 在AJCC第八版系统中,对预测主要不良结果的灵敏度为0.5和特异性为0.97.
- 这两种系统均实现了0.74.4的一致性指数.
结论:
- 现有的分期系统,包括AJCC第8版和BWH系统,是预测皮肤状细胞癌的不良结果的宝贵工具.
- 这些经过验证的系统可以帮助临床医生对这些皮肤癌患者进行风险分层和管理计划.
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