与非小细胞肺癌相关的CCR5促进体多态性
Tianchang Lu1, Yuhan Shi2, Minyi Wang3
1Department of Immunogenetics, Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China.
International journal of immunogenetics
|November 14, 2023
概括
在C-C化学受体5 (CCR5) 促进体中的遗传变异与非小细胞肺癌 (NSCLC) 风险有关. 特定的CCR5促进分子多态影响转录活性,影响NSCLC发育和免疫细胞透.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
背景情况:
- C-C 化学因子受体5 (CCR5) 对免疫细胞功能和癌症进展至关重要.
- 较高的CCR5表达与更好的肺癌存活率和免疫细胞透率的增加有关.
- 在非小细胞肺癌 (NSCLC) 中,CCR5促进体多态的作用需要进一步研究.
研究的目的:
- 调查中华汉族人群中CCR5促进体多态性和NSCLC风险之间的关联.
- 分析这些多形态对CCR5促进体转录活性的影响.
主要方法:
- 一项涉及449名NSCLC患者和516名对照者的病例控制研究.
- 使用测序和双露西法酶记者分析检测多态性.
- 对CCR5表达和生存相关性进行公开数据资源的in silico分析.
主要成果:
- 在NSCLC患者中,rs1799987-AA的频率显著更高 (递归模型,p=0.007).
- rs1799987的G等位基因与增加NSCLC风险有关 (主要模型,p=0.003).
- 哈普洛型H5 (A-G-G-T-G-C) 显著增加了NSCLC风险 (OR=16.09,p<0.0001) 并降低了CCR5促进体活性.
结论:
- CCR5促进物多态性与NSCLC易感性有显著的关联.
- 这些遗传变异影响CCR5的转录活性,影响NSCLC的发展.
- 这些发现强调了CCR5在NSCLC病原和免疫反应中的潜在作用.
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