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Updated: Jul 11, 2025

Enhanced Crosslinking Immunoprecipitation eCLIP Method for Efficient Identification of Protein-bound RNA in Mouse Testis
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使用DEWSeqq在eCLIP数据中改善了RNA结合蛋白结合位点的发现.

Thomas Schwarzl1, Sudeep Sahadevan1, Benjamin Lang2

  • 1European Molecular Biology Laboratory (EMBL), Meyerhofstraße 1, 69117 Heidelberg, Germany.

Nucleic acids research
|November 14, 2023
PubMed
概括

DEWSeq通过使用复制信息和输入控制来增强来自eCLIP测序数据的RNA结合蛋白 (RBP) 位点识别. 这个新的R/生物导体包显著增加了检测到的RBP结合点的数量和生物相关性.

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RNA-seq03:21

RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
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