轻度认知障碍和阿尔茨海默病患者的基于时间和事件的前性记忆:系统性审查和元分析
Rafael Román-Caballero1,2, Giovanna Mioni3
1Mind, Brain and Behavior Research Center (CIMCYC), University of Granada, Granada, Spain.
Neuropsychology review
|November 14, 2023
概括
在阿尔茨海默病 (AD) 和轻度认知障碍 (MCI) 患者中证实了前性记忆 (PM) 缺陷. 令人惊的是,这些PM损害随着时间的推移而减少,可能是由于研究设计的改进.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 老年学是一门学科.
背景情况:
- 预期记忆 (PM) 对于整个生命周期的日常独立至关重要.
- 情节性记忆和执行功能的缺陷是PM的关键,是轻度认知障碍 (MCI) 和阿尔茨海默病 (AD) 的标志.
- 由于老年人口日益增长,了解老龄化和认知障碍的PM下降至关重要.
研究的目的:
- 对患有MCI和AD的个体的前性记忆表现进行元分析.
- 为了比较AD患者,MCI患者和健康对照者的PM能力.
- 调查随着时间的推移PM赤字和出版偏差的趋势.
主要方法:
- 对46项涉及4668名参与者的研究进行了元分析 (2115名患者,2553名对照).
- 包括来自AD和MCI研究的63个独立样本和129个效果大小.
- 分析了基于事件和基于时间的PM之间的差异.
主要成果:
- 与MCI和对照组相比,在AD患者中证实显著降低PM能力.
- 在患者中,基于事件和基于时间的PM之间没有发现明确的差异.
- 观察到多年来MCI和AD患者的PM缺陷减少,以及减少出版偏差.
结论:
- 在AD和MCI中,PM赤字显而易见,AD显示出更大的损伤.
- 观察到的颗粒物赤字的减少可能与研究方法的进步有关.
- 建议使用强大的设计进行进一步的研究,以了解认知障碍中的PM下降.
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