结直肠癌免疫治疗的现状和前景
Weiqing Yang1, Huifen Zheng1, Weibin Lv1
1Department of Oncology, The First Affiliated Hospital of Wannan Medical College, Wuhu, China.
International journal of colorectal disease
|November 14, 2023
概括
结肠直肠癌免疫疗法在晚期癌症中显示出有前途. 本综述强调了微卫星不稳定性高 (MSI-H) 和微卫星稳定 (MSS) 的结直肠癌的当前治疗方法,以及关键生物标志物.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 免疫治疗是一种免疫疗法.
背景情况:
- 结肠直肠癌是中国的主要胃肠道恶性瘤.
- 尽管化疗,放射治疗和向疗法的进展,但晚期结直肠癌的预后仍然很差.
- 迫切需要新的治疗策略来提高生存率.
研究的目的:
- 审查结直肠癌免疫疗法的最新进展.
- 讨论免疫疗法在结直肠癌治疗中的未来前景.
- 探索潜在的组合疗法选择,并确定有价值的生物标志物.
主要方法:
- 对结直肠癌当前免疫治疗方法的文献综述.
- 对微卫星不稳定性高/缺陷不匹配修复 (MSI-H/dMMR) 和微卫星稳定/高水平不匹配修复 (MSS/pMMR) 的结直肠癌治疗策略的分析.
- 确定有前途的免疫疗法生物标志物.
主要成果:
- 讨论了MSI-H/dMMR结直肠癌的后续线路,第一线和新辅助疗法.
- 为MSS/pMMR结直肠癌提供了组合治疗选择.
- 突出了目前在免疫治疗中使用的有价值的生物标志物.
结论:
- 免疫疗法代表了结直肠癌治疗的重大进步.
- 了解特定的生物标志物对于优化免疫疗法疗效至关重要.
- 对组合疗法的进一步研究有可能改善患者的治疗结果.
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