关节参与可以预测 Chikungunya 在印度登革热综合症的设置
Abhinav Sinha1, Deepali Savargaonkar2, Auley De2
1ICMR-National Institute of Malaria Research, New Delhi, India. abhinavsinha@icmr.gov.in.
Journal of epidemiology and global health
|November 14, 2023
概括
在印度发生登革热和 chikungunya 综合症期间,关节疼痛,胀,和牙出血等特定症状可以帮助预测 chikungunya. 这有助于在疫情爆发期间有效诊断.
科学领域:
- 医学昆虫学 医学昆虫学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 登革热和 chikungunya 在印度是特有的,经常在流行病中共同发生,称为"综合症".
- 印度2016年综合性流行病使诊断资源紧张,特别是在城市地区.
- 诊断基础设施有限,需要在疫情期间有效地分层患者.
研究的目的:
- 在发烧患者中确定可靠预测 chikungunya 的临床症状.
- 指导在综合症期间合理引导患者进行特定的奇孔古尼亚诊断.
- 在临床表现的基础上区分奇孔尼亚和登革热.
主要方法:
- 一项涉及新德里的ICMR-NIMR发烧诊所978名发烧患者的横截面研究.
- 对34个参数进行临床数据收集,随后进行双变量和多变量统计分析.
- 临床症状与 chikungunya 诊断之间的关联分析.
主要成果:
- 双变量分析确定了关节疼痛,胀,皮疹,红斑,虚弱,,失去味觉,红眼睛和牙出血作为重要的预测因素.
- 多变量分析显示,关节疼痛 (肘部),关节胀,和牙出血是奇孔古尼亚的统计学显著预测因素.
- 这些症状与登革热相比,与 chikungunya 有显著的关联.
结论:
- 临床医生可以利用特定的症状 (关节疼痛,胀,,牙出血) 优先进行奇孔尼亚检测.
- 这种方法优化了在登革热-奇孔古尼亚综合症环境中针对特定诊断的资源配置.
- 有效的患者道改善了诊断准确性和同时发生的疫情期间的管理.
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