西班牙裔/拉丁裔的遗传风险预测:里程碑,挑战和社会伦理考虑

Betzaida L Maldonado1,2,3, Daniel G Piqué4,5, Robert C Kaplan6

  • 1Human Medical Genetics & Genomics Graduate Program, University of Colorado-Anschutz Medical Campus, Aurora, CO, USA. betzaida.maldonado@cuanschutz.edu.

PubMed
概括

多基因分数 (PGSs) 在西班牙裔/拉丁裔等多元人口中显示出有限的预测能力,原因是祖先偏见. 改善GWAS多样性对于公平的遗传风险预测和个性化医疗至关重要.

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