COVID-19对支气管炎症恶化率的影响:一项回顾性美国保险索赔研究
Annika Åstrand1, Steven J Kiddle2, Rohith Siva Ganesh Mudedla3
1Late-Stage Development, Respiratory & Immunology, AstraZeneca, Gothenburg, Sweden.
Annals of the American Thoracic Society
|November 14, 2023
概括
随着COVID-19的流行,美国的支气管病患者的恶化明显减少. 这项研究发现,在疫情期间,呼吸道感染和住院病例较少,这突显了潜在的公共卫生益处.
科学领域:
- 肺部医学 肺部医学
- 流行病学 流行病学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 支气管病是一种慢性肺部疾病,其特征是不可逆转的支气管扩张,炎症和痕.
- 支气管切除症中粘膜干净度受损增加了对呼吸道感染和恶化的敏感性.
- 以前的研究表明,在英国队列中,COVID-19大流行期间支气管切除症恶化减少.
研究的目的:
- 调查COVID-19大流行对美国商业保险人口中支气管切除症恶化频率的影响.
- 为了测试美国支气管切除症患者在大流行期间经历的恶化情况较少的假设.
主要方法:
- 使用非识别健康保险索赔数据 (Optum Clinformatics Data Mart) 的回顾性观察队列研究.
- 纳入标准:美国18岁以上的支气管病患者;排除其他重大呼吸道疾病.
- 支气管切除症恶化率在流行病前一年与流行病第一年之间的比较.
主要成果:
- 观察到患者每年中位数恶化病例的统计学显著下降 (1对0;P<0.01).
- 在流行病的第一年,经历零恶化症状的患者比例大幅增加 (57%与24%相比;P <0.01).
- 在一项基于美国人口的研究中,使用ICD码对支气管病变的发现是一致的.
结论:
- 与前两年相比,COVID-19流行病的第一年,支气管切除症恶化率显著降低.
- 这种减少表明,流行病相关措施对支气管切除症患者的恶化频率有潜在的公共卫生益处.
- 需要进一步的研究,以了解这种观察到的恶化的减少背后的机制.
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