生活质量支气管切开症呼吸道症状尺度预测了支气管切开症成年人的恶化风险:一项前性观察研究
Yong-Hua Gao1,2, Hui-Zhen Zheng1,2, Hai-Wen Lu1,2
1Department of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, and.
Annals of the American Thoracic Society
|November 14, 2023
概括
根据QoL-B-RSS呼吸道症状尺度 (QoL-B-RSS) 测量出的基线症状严重程度,预测了支气管切除症患者未来的恶化情况. 与病史一起评估症状有助于预防恶化的早期干预.
科学领域:
- 肺部医学 肺部医学
- 呼吸系统疾病研究 呼吸系统疾病研究
背景情况:
- 支气管切除症的恶化构成了重大的临床挑战.
- 预测基线症状严重程度对支气管切开症纵向恶化风险的预测价值仍然未被证明.
研究的目的:
- 通过使用呼吸系统症状量表 (QoL-B-RSS) 评估出发症状是否能预测支气管病患者未来的恶化风险.
- 评估单个QoL-B-RSS组件分数的预测能力.
主要方法:
- 研究了来自三所三级医院的436名成年支气管切除症患者的队列.
- 使用QoL-B-RSS (0-100级,较低的分数表明严重程度更高) 测量了基线症状.
- 分析了连续QOL-B-RSS得分与12个月恶化风险,住院和第一次恶化的时间之间的关联,并对混因素进行了调整.
主要成果:
- 较低的基线QoL-B-RSS得分 (表明更严重的症状) 与恶化的风险增加 (每10点下降的RR1.25) 和住院 (RR1.24) 显著相关.
- 症状严重程度预测了第一个恶化 (HR 1.12) 的时间缩短,并且在预测频繁的恶化和住院治疗方面与恶化史相似.
- 在单个QoL-B-RSS组件中,更严重的症状与更高的恶化可能性相关.
结论:
- 使用 QoL-B-RSS 的基线症状评估是识别高风险未来恶化支气管切除症患者的宝贵工具.
- 将症状评估与恶化的病史相结合,可以提高及时和成本效益的预防性干预措施的实施.
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