格林素反应的中基底下垂体神经元介导运动相关的食物摄入和运动耐力
Omprakash Singh1, Sean B Ogden1, Salil Varshney1
1Center for Hypothalamic Research, Department of Internal Medicine.
JCI insight
|November 14, 2023
概括
大脑中的格林林反应神经元.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 运动生理学 运动生理学
背景情况:
- 格雷林是一种氧化激素,影响运动耐力和运动后的食.
- 在高强度间歇运动 (HIIE) 后,格林林水平增加.
- 没有生长激素分泌剂受体 (GHSR-null) 的小鼠在HIIE后表现出减少的食和跑步能力.
研究的目的:
- 为了研究林响应基底下垂体中介质神经元 (MBH) 在调解炼反应中的作用.
- 为了确定抑制这些神经元是否会影响养和耐力.
主要方法:
- 在 Ghsr-IRES-Cre小鼠中,使用 AAV2-hSyn-DIO-hM4(Gi) -mCherry 和克洛沙平-N-氧化物,对表达GHSR的MBH神经元进行化学代谢抑制.
- 在HIIE和ghrelin管理后评估食物摄入量.
- 评估了运动耐力,血糖和血液乳酸水平.
- 测量了葡萄糖耐受性和MBH Ghsr表达.
主要成果:
- 抑制表达GHSR的MBH神经元抑制后HIIE食物摄入.
- 运动期间减少最大跑步距离和增加血糖/乳酸盐.
- 在服用格林后,食物摄入量减少.
- HIIE增加了MBH Ghsr表达;葡萄糖耐受性没有受到影响.
结论:
- 激活对ghrelin敏感的MBH神经元对于HIIE后的典型食反应至关重要.
- 这些神经元在运动耐力协议期间需要正常运行性能.
相关概念视频
01:30Regulation of Food Intake
247
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
247
01:40Hormonal Regulation
43.5K
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
43.5K
01:27Exercise and Muscle Performance
1.5K
Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
1.5K
01:24Glucagon-like Receptor Agonists
332
Incretins include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which stimulate insulin secretion post-meals. In type 2 diabetes, GIP's efficacy is reduced, making GLP-1 a viable drug target. GIP originates from preproGIP.
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by...
332
01:02Glucose Homeostasis: Regulation of Blood Glucose
1.7K
Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
1.7K
01:16Hormones Regulating Blood Glucose
3.4K
Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
In addition to accelerating glucose uptake and utilization, insulin has...
In addition to accelerating glucose uptake and utilization, insulin has...
3.4K