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形态动力学模型和形态选择的比较,以优先考虑euploid胚胎:一个多中心队列研究

Thomas Bamford¹, Rachel Smith², Selina Young²

¹Tommy's National Centre for Miscarriage Research, Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, UK.

Human reproduction (Oxford, England)

|November 14, 2023

概括

与胚胎学家的评估相比,像PREFER和LB这样的形态动力学模型显著改善了euploid胚胎选择. 这些人工智能驱动的工具为试管婴儿提供了更好的优先级,提高了成功率.

科学领域:

生殖医学生殖医学
胚胎学胚胎学
在体外受精 (IVF)

背景情况:

形态动力学算法分析了胚胎随着时间的推移而发展.
PREFER和LB模型预测了euploidy和活产生的结果.
目前的方法依赖于胚胎学家的形态评估.

研究的目的:

为了比较形态动力学模型与胚胎学家选择优先考虑euploid胚胎的有效性.
评估 PREFER 和 LB 模型对欧体胚胎排名高于任意或专家选择的能力.

主要方法:

一项对1958年9家英国试管婴儿诊所的胚胎囊活检的队列研究.
将PREFER和LB模型与任意选择和四位盲目的胚胎学家进行比较.
用于性能指标的正常化贴现累积收益 (NDCG) 和曲线下的面积 (AUC) 的利用.

主要成果:

PREFER和LB模型比胚胎学家 (39%) 和任意选择 (37%) 实现了更高的幼胚胎优先级 (47%和46%).
对于PREFER (0.96) 和LB (0.95) 的NDCG得分明显高于胚胎学家选择 (0.87).
形态学评估没有显著提高形态动力学模型的性能.

结论:

形态动力学模型在优先考虑转移euploid胚胎方面表现出卓越的性能.
这些模型为IVF胚胎选择提供了更客观,更有效的方法.
进一步整合形态动力学分析可以优化试管婴儿治疗结果.

关键词:

胚胎排名排名胚胎排名胚胎选择胚胎选择形态动力学形态动力学进行非侵入性胚胎评估.普洛伊迪 (Ploidy) 是一个平的人.时间过去了,时间过去了.

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