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Updated: Jul 11, 2025

Examination of Proteins Bound to Nascent DNA in Mammalian Cells Using BrdU-ChIP-Slot-Western Technique
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Published on: January 14, 2016

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染色体重塑器CHD4通过控制全球染色体结构来维持尤文肉瘤细胞生存

Joana Graca Marques1, Blaz Pavlovic1, Quy A Ngo1

  • 1Department of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.

Cancer research
|November 14, 2023
PubMed
概括

螺旋酶CHD4通过调节染色质结构和抑制DNA损伤,对尤宁肉瘤细胞生存至关重要. 向CHD4可以提高对基因毒剂的敏感性,为这种侵袭性癌症提供新的治疗策略.

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